Studies: Natural Immunity to COVID Offers Some People “Bulletproof Protection” Against Variants

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Study finds natural immunity to Covid offers bulletproof protection against variants

A series of new studies have shown that natural immunity to Covid offers some people “bulletproof protection” against variants that may emerge in the future.

Over the past several months, a series of studies has found that some people possess a “superhuman” immune response against SARS-CoV-2, the coronavirus that causes COVID-19. Their bodies produce extremely high levels of antibodies, which their bodies produce with great flexibility — likely capable of fighting off most variants circulating in the world and also likely effective against future variants.

“One could reasonably predict that these people will be quite well protected against most — and perhaps all of — the SARS-CoV-2 variants that we are likely to see in the foreseeable future,” says Paul Bieniasz, a virologist at Rockefeller University. reports: In a study published online last month, Bieniasz and his colleagues found antibodies in these individuals that can strongly neutralize the six variants of concern tested, including delta and beta, as well as several other viruses related to SARS-CoV-2, including one in bats, two in pangolins and the one that caused the first coronavirus pandemic, SARS-CoV-1.

“This is being a bit more speculative, but I would also suspect that they would have some degree of protection against the SARS-like viruses that have yet to infect humans,” Bieniasz says.

So who is capable of mounting this “superhuman” or “hybrid” immune response?

People who have had a “hybrid” exposure to the virus. Specifically, they were infected with the coronavirus in 2020 and then immunized with mRNA vaccines this year. “Those people have amazing responses to the vaccine,” says virologist Theodora Hatziioannou at Rockefeller University, who also helped lead several of the studies. “I think they are in the best position to fight the virus. The antibodies in these people’s blood can even neutralize SARS-CoV-1, the first coronavirus, which emerged 20 years ago. That virus is very, very different from SARS-CoV-2.”

In fact, these antibodies were even able to deactivate a virus engineered, on purpose, to be highly resistant to neutralization. This virus contained 20 mutations that are known to prevent SARS-CoV-2 antibodies from binding to it. Antibodies from people who were only vaccinated or who only had prior coronavirus infections were essentially useless against this mutant virus. But antibodies in people with the “hybrid immunity” could neutralize it.

These findings show how powerful the mRNA vaccines can be in people with prior exposure to SARS-CoV-2, she says. “There’s a lot of research now focused on finding a pan-coronavirus vaccine that would protect against all future variants. Our findings tell you that we already have it.

“But there’s a catch, right?” she adds: You first need to be sick with COVID-19. “After natural infections, the antibodies seem to evolve and become not only more potent but also broader. They become more resistant to mutations within the [virus].”

Hatziioannou and colleagues don’t know if everyone who has had COVID-19 and then an mRNA vaccine will have such a remarkable immune response. “We’ve only studied the phenomena with a few patients because it’s extremely laborious and difficult research to do,” she says.

But she suspects it’s quite common. “With every single one of the patients we studied, we saw the same thing.” The study reports data on 14 patients.

Several other studies support her hypothesis — and buttress the idea that exposure to both a coronavirus and an mRNA vaccine triggers an exceptionally powerful immune response. In one study, published last month in The New England Journal of Medicine, scientists analyzed antibodies generated by people who had been infected with the original SARS virus — SARS-CoV-1 — back in 2002 or 2003 and who then received an mRNA vaccine this year.

Remarkably, these people also produced high levels of antibodies and — it’s worth reiterating this point from a few paragraphs above — antibodies that could neutralize a whole range of variants and SARS-like viruses.

Now, of course, there are so many remaining questions. For example, what if you catch COVID-19 after you’re vaccinated? Or can a person who hasn’t been infected with the coronavirus mount a “superhuman” response if the person receives a third dose of a vaccine as a booster?

Hatziioannou says she can’t answer either of those questions yet. “I’m pretty certain that a third shot will help a person’s antibodies evolve even further, and perhaps they will acquire some breadth [or flexibility], but whether they will ever manage to get the breadth that you see following natural infection, that’s unclear.”

Immunologist John Wherry, at the University of Pennsylvania, is a bit more hopeful. “In our research, we already see some of this antibody evolution happening in people who are just vaccinated,” he says, “although it probably happens faster in people who have been infected.”

In a recent study, published online in late August, Wherry and his colleagues showed that, over time, people who have had only two doses of the vaccine (and no prior infection) start to make more flexible antibodies — antibodies that can better recognize many of the variants of concern.

So a third dose of the vaccine would presumably give those antibodies a boost and push the evolution of the antibodies further, Wherry says. So a person will be better equipped to fight off whatever variant the virus puts out there next.

“Based on all these findings, it looks like the immune system is eventually going to have the edge over this virus,” says Bieniasz, of Rockefeller University. “And if we’re lucky, SARS-CoV-2 will eventually fall into that category of viruses that gives us only a mild cold.”


  1. Well who had that variety back then? Noinevuvecwvervknown. Meanwhile mre relevbybresearch sas that people who last years variety and who then get an Mrna vaccine are, I thin it was 40%mote likely than those who have never had it, to die.

  2. This is more bull. The immunity comes from having had the covid. There is no immunity granted by the mRNA ‘vaccines’. The ‘vaccines’ will put you in the hospital or in the grave. If you survive it your immune system will be compromised and you will have to take the shot every three months for the rest of your life along with pills every day. I prefer natural immunity; I got my Ivermectin & Hydroxychloroquine and my COVID test kits. If I get sick I will get well in a matter of days. I got the drugs from India though I order thru Canada. It took a month for each drug. So you better order it before you need it.

    On the other hand I have not worn masks or socially distanced and I am still not sick! I need t find some one who has the COVID and catch the disease from them so I can beat it with my ivermectin and give myself the life long immunity. No ‘vaccine’ for me. It isn’t even a ‘vaccine’ if it does not give immunity and it does not give immunity.

    • The tests can’t tell the difference from the common cold and they leave traces of hydrogel & lithium inside you. You’re better off just loving your life instead of actively trying to catch something.

  3. So, there is no need for a vaccine among the vast majority of us.

    Now, last week, the CDC quietly releases their updated ( MMWR) Morbidity and Mortality Weekly Report (August 2020 to August 2021). Surprise! It and previous data confirm what the CDC has known all along.

    The survivability rate under age 18 from Covid is 99.99997%

    1,790 hospitalizations of patients below the age of 18 recorded (August 2020 to August 2021)
    Those hospitalized may not be related to Covid symptoms but tested positive. The median length of stay ranged from 2 to 3 days during the entire period.

    Over 25% of those 1,790 were related to older adolescents with new-onset cardiac complications post-vaccine.

    The incidence of ventilators being needed, “ranged from 0% to 3% and was highest in October 2020.”

    The mortality rate for children who were hospitalized is 0.04%

    Children are not super spreaders.

    Even factoring in the latest data with Delta Variance uptick- Children under age 17 account for 0.057% of all Covid – involved deaths. ( deaths with positive infection but may not have caused death included.)

    In the U.S. 335 children have died since the start of the pandemic. A study done by Johns Hopkins and FAIR Health showed that all of the children that died from April 2020 to August 2020 had immune problems or were chronically ill.

    Most Americans think CDC has not had effective communication with the public.

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